Polyclonal Rabbit Anti Human Herstatin

HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

The erbb2 antibody was raised in rabbits by immunization with the recombinant Human erbb2 (43.4 kDa, 397 a.a. and one extra AA, N-terminal Methionin) purified from E. coli.

The lyophilized antibody remains stable and fully active until the expiry date when stored at -20C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles and store frozen at -80C. Reconstituted antibody can be stored at 4C for a limited period of time, it does not show decline in activity after one week at 4C.