Item no. |
NKM-ATGP4102-500ug |
Manufacturer |
NKMAX
|
Amount |
500ug |
Applications |
SDS-PAGE |
Specific against |
Human |
Conjugate/Tag |
His-Tag |
Purity |
> 95% by SDS-PAGE |
Citations |
Ravetch JV., et al. (1989) J Exp Med. 170:481-497.<br> Ferrara C., et al. (2011) Proc Natl Acad Sci U S A. 108:12669-12674. |
NCBI |
NP_001121065.1 |
Alias |
Low affinity immunoglobulin gamma Fc region receptor III-A,low affinity immunoglobulin gamma Fc region receptor III-A isoform c, IgG Fc receptor III-A, CD16-II, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcgammaRIIIA, FcR-10, IgG Fc receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, FCGRIII, IGFR3, IMD20, CD16 |
Similar products |
ATGP4102-10ug, ATGP4102-20ug, ATGP4102-50ug, ATGP4102-100ug, ATGP4102-250ug, ATGP4102-500ug, ATGP4102-1mg, ATGP4102-10, ATGP4102-20, ATGP4102-50, ATGP4102-100, ATGP4102-250, ATGP4102-500, ATGP4102-1, ATGP3449-10ug, ATGP3449-20ug, ATGP3449-50ug, ATGP3449-100ug, ATGP3449-250ug, ATGP3449-500ug, ATGP3449-1mg, ATGP3449-10, ATGP3449-20, ATGP3449-50, ATGP3449-100, ATGP3449-250, ATGP3449-500, ATGP3449-1 |
Available |
|
Domain |
18-208aa |
Description |
FCGR3A, also known as low affinity immunoglobulin gamma Fc region receptor III-A, is a multifunctional, low or intermediate affinity receptor, which belongs to the immunoglobulin superfamily. It is expressed on human NK cells as an integral membrane glycoprotein anchored through a transmembrane peptide. It mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Recombinant human FCGR3A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
Concentration |
0.25mg/ml (determined by absorbance at 280nm) |
Formulation |
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
Bioactivity Comment Only |
Measured by its binding ability in a functional ELISA with Human IgG1 Fc (CAT# ATGP4094). |
Manufacturers Gene Category |
Immunology |
Molecular Weight |
22.8 kDa (200aa) |
Endotoxin |
< 1 EU per 1ug of protein (determined by LAL method) |
Bioactivity Comment and Pics |
Human Fc gamma RIIIA/CD16a is coated at 10 ug/ml (100 ul/well) can bind Human IgG1 Fc (CAT# ATGP4094) in a functional ELISA assay. |
Bioassay Procedure |
MRTEDLP KAVVFLEPQW YRVLEKDSVT LKCQGAYSPE DNSTQWFHNE SLISSQASSY FIDAATVDDS GEYRCQTNLS TLSDPVQLEV HIGWLLLQAP RWVFKEEDPI HLRCHSWKNT ALHKVTYLQN GKGRKYFHHN SDFYIPKATL KDSGSYFCRG LFGSKNVSSE TVNITITQGL AVSTISSFFP PGYQ |
Expression System |
Baculovirus |
Predicted nterm |
Ala |
Manufacturers Product Type |
Recombinant Protein |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.