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Dibenz[a,h]anthracene

Dibenz[a,h]anthracene

Item no.	HY-W013053-25mg
Manufacturer	MedChem Express
CASRN	53-70-3
Amount	25 mg
Specific against	other
Purity	98.0
Citations	[1]Amal I Malik, et al. Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a,h]anthracene. Mutagenesis. 2013 Sep;28(5):543-54.<br>[2]K L Platt, et al. Stereoselective metabolism of dibenz(a,h)anthracene to trans-dihydrodiols and their activation to bacterial mutagens. Environ Health Perspect. 1990 Aug:88:37-41.
Alias	DBA; 1,2,5,6-Dibenzanthracene; Benzo[k]tetraphene
Available
Product Description	Dibenz[a, h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a, h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a, h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	278.35
Clinical_Information	Phase 3
Manufacturers Research_Area	Cancer
Solubility	10 mM in DMSO
Manufacturers Target	Apoptosis; DNA/RNA Synthesis; MDM-2/p53
Pathway	Apoptosis; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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Amount: 25 mg

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