« Back
Home /
Fas/CD95, Cynomolgus (HEK293)

Fas/CD95, Cynomolgus (HEK293)

Item no.	HY-P76330-2ug
Manufacturer	MedChem Express
Amount	2 ug
Quantity options	100 ug 10 ug 1 ea 2 ug 50 ug
Specific against	other
Purity	95.0
Citations	[1]Liu C, et al. Differential expression of human Fas mRNA species upon peripheral blood mononuclear cell activation. Biochem J. 1995 Sep 15;310 ( Pt 3)(Pt 3):957-63.<br/>[2]Screaton RA, et al. Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5211-6.<br/>[3]Brenner B, et al. Fas/CD95/Apo-I activates the acidic sphingomyelinase via caspases. Cell Death Differ. 1998 Jan;5(1):29-37.<br/>[4]Lee SM, et al. Stimulation of Fas (CD95) induces production of pro-inflammatory mediators through ERK/JNK-dependent activation of NF-κB in THP-1 cells. Cell Immunol. 2011;271(1):157-62.
Smiles	QVTDISSKGF ELRKIVTTIE TQNLEGLHHE GQFCRNPCPP GERKARDCTV NEDEPDCVPC QEGKEYTDKG HFSSKCRRCR LCDEGHGLEV EINCTRTQNT KCRCKPNFFC NSAVCEHCDP CTKCKHGIIE ECTLTSNTKC KEEDSRSD
Alias	Fas/CD95 Protein, Cynomolgus (HEK293),Cynomolgus,HEK293
Available
Product Description	Fas receptor is a cell surface death receptor, can bind to Fas ligand to form death-inducing signaling complexes, such as Fas associated death domain proteins (FADD)[1][2]. Fas receptor participates in the caspase cascade and regulate the activation of JNK and p38-K downstream. It is also involved in the signaling cascade of ERK/JNK MAPKs, activating MAPK3/ERK1, MAPK8/JNK and NF-κB, which has been implicated in the pathogenesis of various malignant tumors and immune system diseases[3][4]. Macaca mulatta Fas receptor contain a death domain (228-312 a.a.) that plays a key role in regulating programmed death. Fas/CD95 Protein, Cynomolgus (HEK293) has a full length of 173 amino acids (M1-D173), produced in HEK293 cells with tag free.
StorageTemperature	Stored at -20°C for 2 years
Shipping	Blue Ice
MolecularWeight	Approximately 19-27 kDa due to the glycosylation.
Manufacturers Product type	Recombinant Proteins

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 2 ug

available

Request delivery time