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(±)5-HEPE

(±)5-HEPE

Item no.	HY-N7801
Manufacturer	MedChem Express
CASRN	83952-40-3
Amount	1 ea
Specific against	other
Citations	[1]Powell, et al. Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils. J. Lipid Res. 36, 2590-2598 (1995).
Smiles	CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(O)CCCC(O)=O
Available
Product Description	(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.
Shipping	Room temperature
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	318.45
Clinical Information	No Development Reported
Manufacturers Research Area	Metabolic Disease
Target	Others
Manufacturers Target	Others
Manufacturers Pathway	Others
Manufacturers Product type	Natural Products

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