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Trovafloxacin

Trovafloxacin

Item no.	HY-A0170-25mg
Manufacturer	MedChem Express
CASRN	147059-72-1
Amount	25 mg
Quantity options	100 mg 10 mM x 1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Specific against	other
Purity	98.99
Citations	[1]Giustarini G, et al. The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915.<br/>[2]Poon IK, et al. Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature. 2014 Mar 20;507(7492):329-34.<br/>[3]Gootz TD, et al. Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob Agents Chemother. 1996 Dec;40(12):2691-7.
Smiles	O=C(C1=CN(C2=CC=C(F)C=C2F)C3=NC(N4C[C@@]5([H])[C@H](N)[C@@]5([H])C4)=C(F)C=C3C1=O)O
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Product Description	Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	416.35
Clinical Information	Launched
Manufacturers Research Area	Infection
Solubility	DMSO : 10 mg/mL (ultrasonic; adjust pH to 2 with 1M HCl)\|DMSO : 9.09 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Target	Antibiotic; Bacterial; Topoisomerase
Manufacturers Target	Antibiotic; Bacterial; Topoisomerase
Isoform	Quinolone
Manufacturers Pathway	Anti-infection; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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