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Cisplatin

Cisplatin

Item no.	HY-17394-10mg
Manufacturer	MedChem Express
CASRN	15663-27-1
Amount	10 mg
Specific against	other
Purity	99.84
Citations	[1]Wu K, et al. Cisplatin inhibits the progression of bladder cancer by selectively depleting G-MDSCs: A novel chemoimmunomodulating strategy. Clin Immunol. 2018 Aug;193:60-69.<br>[2]Hall MD, et al. Say no to DMSO: dimethylsulfoxide inactivates cisplatin, NSC 241240, and other platinum complexes. Cancer Res. 2014 Jul 15;74(14):3913-22.<br>[3]Shimeda Y, et al. Protective effects of capsaicin against cisplatin-induced nephrotoxicity in rats. Biol Pharm Bull. 2005 Sep;28(9):1635-8.<br>[4]Cummings BS, et al. Cisplatin-induced renal cell apoptosis: caspase 3-dependent and -independent pathways. J Pharmacol Exp Ther. 2002 Jul;302(1):8-17.<br>[5]Park HR, et al. Enhanced antitumor efficacy of cisplatin in combination with HemoHIM in tumor-bearing mice. BMC Cancer. 2009 Mar 17;9:85.<br>[6]Wang X, et al. Requirement for ERK activation in cisplatin-induced apoptosis. J Biol Chem. 2000 Dec 15;275(50):39435-43.<br>[7]Noha Alassaf, et al. Autophagy and necroptosis in cisplatin-induced acute kidney injury: Recent advances regarding their role and therapeutic potential. Front Pharmacol. 2023 Jan 30:14:1103062. <br>[8]Ryan M Williams, et al. Kidney-Targeted Redox Scavenger Therapy Prevents Cisplatin-Induced Acute Kidney Injury. Front Pharmacol. 2022 Jan 3:12:790913.
Smiles	Cl[Pt](Cl)([NH3])[NH3]
Alias	cis-Platinum; CDDP; cis-Diaminodichloroplatinum
Available
Product Description	Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy[1][2][3].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	300.05
Clinical_Information	Launched
Manufacturers Research_Area	Cancer
Solubility	DMF : 14.17 mg/mL (ultrasonic; warming)\|DMSO : 100 mg/mL (ultrasonic)\|H2O : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Autophagy; DNA Alkylator/Crosslinker; Ferroptosis
Pathway	Apoptosis; Autophagy; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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