« Back
Home /
Phthalimidinoglutarimide-piperidine-NH2

Phthalimidinoglutarimide-piperidine-NH2

Item no.	HY-163234
Manufacturer	MedChem Express
CASRN	2591197-83-8
Amount	1 ea
Specific against	other
Citations	[1]Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453.<br>[2]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.<br>[3]Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.
Available
Product Description	Phthalimidinoglutarimide-piperidine-NH2 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Phthalimidinoglutarimide-piperidine-NH2 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
Shipping	Room temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	342.39
Clinical_Information	No Development Reported
Manufacturers Research_Area	cancer
Solubility	10 mM in DMSO
Manufacturers Target	Autophagy; Ligands for E3 Ligase
Pathway	Autophagy; PROTAC
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 1 ea

available

Request delivery time