ML-T7

Item no.	HY-163028-100mg
Manufacturer	MedChem Express
CASRN	459789-75-4
Amount	100 mg
Quantity options	1 ea 100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Specific against	other
Purity	99.85
Citations	[1]Ma S, et al. Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models. Sci Transl Med. 2023 Nov 15;15(722):eadg6752.
Smiles	O=C1C2=C(C(C13OC(C4C(N(C5=CC=C(C=C5Cl)Cl)C(C43)=O)=O)C6=CC=C(C)C=C6)=O)C=CC=C2
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Product Description	ML-T7 is a potent Tim-3 inhibitor. ML-T7 blocks Tim-3 interactions with PtdSer and CEACAM1. ML-T7 not only enhances the antitumor activity of adoptive transfer therapy with cytotoxic T lymphocytes (CTLs) and CAR T cells but also increases the effector function of T cell. ML-T7 promotes NK cells’ killing activity against tumor cells and DC antigen-presenting capacity. ML-T7 directly exerts antitumor efficacy in preclinical tumor models either alone or in combination with Nivolumab (HY-P9903A). ML-T7 can be used for tumor immunotherapy research[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	506.33
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 66.67 mg/mL (ultrasonic)
Target	Tim3
Manufacturers Target	Tim3
Manufacturers Pathway	Immunology/Inflammation
Manufacturers Product type	Reference compound

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