PT-179

Item no.	HY-160695-10mg
Manufacturer	MedChem Express
CASRN	2924858-25-1
Amount	10 mg
Quantity options	100 mg 10 mg 25 mg 50 mg 5 mg
Specific against	other
Purity	99.91
Citations	[1]Mercer JAM, et al. Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science. 2024 Mar 15;383(6688):eadk4422.
Smiles	O=C1C2=CC=C(N3CCOCC3)C=C2C(N1C4C(NC(CC4)=O)=O)=O
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Product Description	PT-179 is an orthogonal Thalidomide (HY-14658) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein. For example, PT-179 binds to the ubiquitin ligase substrate receptor cereblon by forming a complex with SD40 and efficiently degrades proteins N- or C-terminally fused to SD40 or SD36 (DC50 for eGFP: 4.5 nM and 14.3 nM). PT-179 can be used to develop compact protein degradation tagging platforms[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	343.33
Clinical Information	No Development Reported
Manufacturers Research Area	cancer
Solubility	DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Ligands for E3 Ligase; Molecular Glues
Manufacturers Target	Ligands for E3 Ligase; Molecular Glues
Manufacturers Pathway	PROTAC
Manufacturers Product type	Reference compound

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