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MC-Gly-Gly-Phe-Gly-GABA-Exatecan

MC-Gly-Gly-Phe-Gly-GABA-Exatecan

Item no.	HY-160649-5mg
Manufacturer	MedChem Express
CASRN	1599439-52-7
Amount	5 mg
Specific against	other
Purity	99.72
Citations	[1]Hettmann T, et al., Anti-her3 antibody-drug conjugate. Patent WO2015155998<br>[2]Ogitani Y, et al., Wide application of a novel topoisomerase I inhibitor-based drug conjugation technology. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5069-5072.
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Product Description	MC-Gly-Gly-Phe-Gly-GABA-Exatecan is an agent linker conjugate for ADC, with an inhibitor for Topoisomerase Exatecan (HY-13631) with IC50 of 22 μM. MC-Gly-Gly-Phe-Gly-GABA-Exatecan targets various antibodies, exhibits cytotoxic and antitumor efficacy in vitro and in vivo[1][2].
StorageTemperature	-20°C (Powder, sealed storage, away from moisture and light)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	1032.08
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturers Target	Drug-Linker Conjugates for ADC; Topoisomerase
Pathway	Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Manufacturers Product type	ADC Related

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