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UNC8153 (TFA)

UNC8153 (TFA)

Item no.	HY-157251-5mg
Manufacturer	MedChem Express
CASRN	2929304-61-8
Amount	5 mg
Quantity options	1 ea 10 mg 5 mg
Specific against	other
Purity	99.91
Citations	[1]Ronan P Hanley, et al. Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. J Am Chem Soc. 2023 Apr 12;145(14):8176-8188.
Smiles	O=C(C(F)(F)F)O.O=C(C1=CC=C(CN(C2CC2)C(C3=CC=C4NC(COC4=C3)=O)=O)C=C1)NC5=CC=C(C(NCCCCCCN)=O)C=C5
Available
Product Description	UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2[1].
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	697.70
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Histone Methyltransferase
Manufacturers Target	Histone Methyltransferase
Manufacturers Pathway	Epigenetics
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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