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Enpp-1-IN-19

Enpp-1-IN-19

Item no.	HY-155457-100mg
Manufacturer	MedChem Express
CASRN	2738583-25-8
Amount	100 mg
Specific against	other
Purity	99.28
Citations	[1]Cho Y et al. Discovery of Orally Bioavailable Phthalazinone Analogues as an ENPP1 Inhibitor for STING-Mediated Cancer Immunotherapy. J Med Chem. 2023 Nov 23;66(22):15141-15170.
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Product Description	Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP hydrolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 increases anti-PD-L1 responses and inhibits tumor growth in CT26 syngeneic models. Enpp-1-IN-19 also enhances STING-mediated type I interferon responses, induces immune memory, and prevents tumor recurrence[1].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
MolecularWeight	344.39
Clinical_Information	No Development Reported
Manufacturers Research_Area	cancer
Solubility	DMSO : 125 mg/mL (ultrasonic)
Manufacturers Target	Phosphodiesterase (PDE); STING
Pathway	Immunology/Inflammation; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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