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RS-127445 (hydrochloride)

RS-127445 (hydrochloride)

Item no.	HY-15419-25mg
Manufacturer	MedChem Express
CASRN	199864-86-3
Amount	25 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Specific against	other
Purity	99.78
Citations	[1]Bonhaus DW, et al. RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. Br J Pharmacol. 1999 Jul;127(5):1075-82.<br/>[2]Bassil AK, et al. Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology. Br J Pharmacol. 2009 Sep;158(1):252-8
Smiles	NC1=NC(C(C)C)=CC(C2=C3C=CC=CC3=C(F)C=C2)=N1.[H]Cl
Available
Product Description	RS-127445 hydrochloride is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 hydrochloride shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	317.79
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 125 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Target	5-HT Receptor
Manufacturers Target	5-HT Receptor
Isoform	5-HT2 Receptor; 5-HT3 Receptor; 5-HT5 Receptor; 5-HT6 Receptor
Manufacturers Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

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