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Antitumor agent-81

Antitumor agent-81

Item no.	HY-151799-1mg
Manufacturer	MedChem Express
CASRN	2765180-17-2
Amount	1 mg
Specific against	other
Purity	98.62
Citations	[1]Wang FC, et al. A 1,2,3-Triazole Derivative of Quinazoline Exhibits Antitumor Activity by Tethering RNF168 to SQSTM1/P62. J Med Chem. 2022 Nov 4.
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Product Description	Antitumor agent-81 (compound 5a) is a low cytotoxic P62-RNF168 agonist that promotes the interaction of P62 with RNF168. Antitumor agent-81 induces a decrease in RNF168-mediated H2A ubiquitination and impairs homologous recombination-mediated DNA repair. Antitumor agent-81 also inhibits mice xenograft tumor growth in a dose-dependent manner[1].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	393.40
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	10 mM in DMSO
Manufacturers Target	E1/E2/E3 Enzyme; p62
Pathway	Autophagy; Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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