I-287

Item no.	HY-148016-50mg
Manufacturer	MedChem Express
CASRN	2014368-93-3
Amount	50 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Specific against	other
Purity	99.02
Citations	[1]Avet C, et.al. The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects. Commun Biol. 2020 Nov 27;3(1):719.
Smiles	O=C(C1=CN=C(N2CCN(C(C)(C2)C)C(C3=CC(N=C(C4=CC=C(C(F)=C4)Cl)C=C5C(C)(C)C)=C5O3)=O)C=C1)O
Available
Product Description	I-287 is a orally active selective PAR2 inhibitor that acting as a negative allosteric regulator on Gαq and Gα12/13 activity and their downstream effectors. I-287 reduces Complete Freund's adjuvant (HY-153808)-induced inflammation in mice and can be used for inflammation/immunology research[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	565.04
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	ERK; Protease Activated Receptor (PAR)
Manufacturers Target	ERK; Protease Activated Receptor (PAR)
Isoform	ERK1; ERK2
Manufacturers Pathway	GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Manufacturers Product type	Reference compound

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