WBC100

Item no.	HY-145898-10mM
Manufacturer	MedChem Express
CASRN	2095780-08-6
Amount	10mM/1mL
Quantity options	10mM/1mL 1 ea 1 mg 5 mg
Specific against	other
Purity	95.0
Citations	[1]Ying Xu, et al. A Selective Small-Molecule c-Myc Degrader Potently Regresses Lethal c-Myc Overexpressing Tumors. Adv Sci (Weinh). 2022 Mar;9(8):e2104344.
Smiles	C[C@@]([C@@]1([H])C2)(CCC3=C1COC3=O)[C@]4([C@@]([C@@](O5)([H])[C@@]65C(C)C)([H])O4)[C@@]7([C@@]2([H])O7)[C@@H]6OC([C@H](N)C(C)C)=O
Alias	14-D-Valine-TPL
Available
Product Description	WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc molecule glue degrader. WBC100 is a c-Myc degrader and targets ubiquitin E3 ligase CHIP mediated 26S proteasome pathway. WBC100 is used for c-Myc overexpressing tumors research[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	459.53
Clinical Information	Phase 1
Manufacturers Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	c-Myc; Molecular Glues
Manufacturers Target	c-Myc; Molecular Glues
Manufacturers Pathway	Apoptosis; PROTAC
Manufacturers Product type	Reference compound

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