SD-208

Item no.	HY-13227-25mg
Manufacturer	MedChem Express
CASRN	627536-09-8
Amount	25 mg
Specific against	other
Purity	99.87
Citations	[1]Uhl M, et al. SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res. 2004 Nov 1;64(21):7954-61.<br>[2]Sun Y, et al. Inhibition of intimal hyperplasia in murine aortic allografts by the oral administration of the transforming growth factor-beta receptor I kinase inhibitor SD-208. J Heart Lung Transplant. 2014 Jun;33(6):654-61.<br>[3]Ge R, et al. Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo. Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4315-30.
Smiles	FC1=CC=C(Cl)C=C1C2=NC3=NC=CN=C3C(NC4=CC=NC=C4)=N2
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Product Description	SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, and > 100-fold selectivity over TGF-βRII.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	352.75
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 9.09 mg/mL (ultrasonic)
Manufacturers Target	TGF-β Receptor
Pathway	TGF-beta/Smad
Manufacturers Product type	Reference compound

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