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Lenalidomide-I

Lenalidomide-I

Item no.	HY-131318-10mg
Manufacturer	MedChem Express
CASRN	2207541-30-6
Amount	10 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Specific against	other
Purity	99.90
Citations	[1]Qin C, et, al. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. J Med Chem. 2018 Aug 9;61(15):6685-6704.
Smiles	O=C(C(N(CC1=C2C=CC=C1I)C2=O)CC3)NC3=O
Available
Product Description	Lenalidomide-I (Compound 72), an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, is used in the recruitment of CRBN protein. Lenalidomide-I can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BET degrader QCA570 (HY-112609)[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	370.14
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 25 mg/mL (ultrasonic)
Target	Ligands for E3 Ligase
Manufacturers Target	Ligands for E3 Ligase
Manufacturers Pathway	PROTAC
Manufacturers Product type	Reference compound

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