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Valemetostat

Valemetostat

Item no.	HY-109108-50mg
Manufacturer	MedChem Express
CASRN	1809336-39-7
Amount	50 mg
Specific against	other
Purity	99.65
Citations	[1]Shimizu J, Kawano F. Exercise-induced histone H3 trimethylation at lysine 27 facilitates the adaptation of skeletal muscle to exercise in mice. J Physiol. 2022 Jul;600(14):3331-3353.<br>[2]Yamagishi M, et al. Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas. Cell Rep. 2019 Nov 19;29(8):2321-2337.e7.<br>[3]Daiichi Sankyo’s EZH1/2 Dual Inhibitor Valemetostat (DS-3201) Receives SAKIGAKE Designation for Treatment of Patients with Relapsed/Refractory Peripheral T-Cell Lymphoma from Japan MHLW.
Smiles	CC1=C(O[C@@](C)([C@]2([H])CC[C@@H](N(C)C)CC2)O3)C3=C(Cl)C=C1C(NCC(C4=O)=C(C=C(C)N4)C)=O
Alias	DS-3201
Available
Product Description	Valemetostat (DS-3201), a first-in-class EZH1/2 dual inhibitor with IC50 values ＜10 nM. Valemetostat can be used for the research of relapsed/refractory peripheral T-cell lymphoma[1][2][3].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	488.02
Clinical_Information	Launched
Manufacturers Research_Area	Cancer
Solubility	DMSO : 70 mg/mL (ultrasonic)
Manufacturers Target	Histone Methyltransferase
Isoform	EZH1
Pathway	Epigenetics
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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