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Relacorilant

Relacorilant

Item no.	HY-109042-25mg
Manufacturer	MedChem Express
CASRN	1496510-51-0
Amount	25 mg
Quantity options	100 mg 10 mg 25 mg 50 mg 5 mg
Specific against	other
Purity	99.37
Citations	[1]Hunt HJ, et al. Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist. J Med Chem. 2017 Apr 27;60(8):3405-3421.
Smiles	O=C(C1=CC(C(F)(F)F)=CC=N1)[C@@]2(CN(S(=O)(C3=CN(C)N=C3)=O)CC4)C4=CC5=C(C=NN5C6=CC=C(F)C=C6)C2
Alias	CORT 125134
Available
Product Description	Relacorilant is a potent, selective and orally bioavailable glucocorticoid receptor antagonist, with a Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively. Relacorilant has the potential for Cushing’s syndrome treatment.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-sugar/lipid metabolism
MolecularWeight	586.56
Clinical Information	Phase 3
Manufacturers Research Area	Cardiovascular Disease; Endocrinology
Solubility	10 mM in DMSO
Target	Glucocorticoid Receptor
Manufacturers Target	Glucocorticoid Receptor
Manufacturers Pathway	Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

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