ML154

Item no.	HY-108626-10mg
Manufacturer	MedChem Express
CASRN	1345964-89-7
Amount	10 mg
Specific against	other
Purity	98.02
Citations	[1]İrem Akçalı, et al. The regulatory role of central neuropeptide-S in locomotion. Peptides. 2023 Dec:170:171110.<br>[2]Annika Thorsell, et al. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats. J Neurosci. 2013 Jun 12;33(24):10132-42.
Alias	NCGC84
Available
Product Description	ML154 (NCGC84) is a selective, brain-penetrant and non-peptide neuropeptide S receptor (NPSR) antagonist with a pA2 of 9.98. ML154 potently inhibits NPS-stimulated cellular calcium, cAMP, and ERK phosphorylation responses with IC50 values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	545.47
Clinical_Information	No Development Reported
Manufacturers Research_Area	Neurological Disease
Solubility	DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Neuropeptide Y Receptor
Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

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