KL001

Item no.	HY-108468-100mg
Manufacturer	MedChem Express
CASRN	309928-48-1
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Specific against	other
Purity	99.68
Citations	[1]Hirota T, et, al. Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31;337(6098):1094-7.<br/>[2]Kelleher FC, et, al. Circadian molecular clocks and cancer. Cancer Lett. 2014 Jan 1;342(1):9-18.<br/>[3]Nangle S, et, al. Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase. Cell Res. 2013 Dec;23(12):1417-9.
Smiles	CS(=O)(N(CC(O)CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CC4=CC=CO4)=O
Available
Product Description	KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis[1][2][3].
StorageTemperature	-20°C (Powder, stored under nitrogen)
Shipping	Blue Ice
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	398.48
Clinical Information	Phase 1
Manufacturers Research Area	Metabolic Disease
Solubility	DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Cryptochrome
Manufacturers Target	Cryptochrome
Manufacturers Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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