A1899

Item no.	HY-103067
Manufacturer	MedChem Express
CASRN	498577-46-1
Amount	1 ea
Specific against	other
Citations	[1]Streit AK, et al. A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J Biol Chem. 2011 Apr 22;286(16):13977-84. <br>[2]Knobloch K, et al. Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide. Naunyn Schmiedebergs Arch Pharmacol. 2002 Nov;366(5):482-7.
Alias	S20951
Available
Product Description	A1899 is a potent and highly selective blocker of the K2P channel TASK-1. A1899 has IC50 values of 35.1 nM and 7 nM for TASK-1 channels expressed in oocytes and CHO cells, respectively. A1899 is also an IKur blocker that can be used for the research of cardiovascular diseases[1][2].
Shipping	Room temperature
MolecularWeight	500.54
Clinical_Information	No Development Reported
Manufacturers Research_Area	Neurological Disease; Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturers Target	Potassium Channel
Pathway	Membrane Transporter/Ion Channel
Manufacturers Product type	Reference compound

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