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Vatalanib

Vatalanib

Item no.	HY-10203-25mg
Manufacturer	MedChem Express
CASRN	212141-54-3
Amount	25 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 ea 25 mg 50 mg 5 mg
Specific against	other
Purity	99.86
Citations	Drug Metab Pharmacokinet. 2017 Jun;32(3):179-188. <br/>J Microbiol Biotechnol. 2015 Aug;25(8):1227-33. <br/>J Pharm Anal. 2023 Sep 11.<br/>Patent. US20170349880A1.<br/>Bioact Mater. 2 January 2022.<br/>Br J Pharmacol. 2019 Sep;176(17):3143-3160. <br/>Evid-Based Compl Alt. 2021 Apr 27.<br/>JCI Insight. 2024 May 22;9(10):e166402.<br/>Kitazato Graduate School of Pharmaceutical Sciences. Kitasato University. 2017.<br/>Oncol Rep. 2016 Mar;35(3):1297-308.<br/>Oxid Med Cell Longev. 18 Jul 2022.<br/>Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.<br/>Ulm University. 2023 Mar 21.<br/>[1]Wood JM, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000, 60(8<br/>[2]Murakami M, et al. Tyrosine kinase inhibitor PTK/ZK enhances the antitumor effects of interferon-α/5-fluorouracil therapy for hepatocellular carcinoma cells. Ann Surg Oncol. 2011, 18(2), 589-596.<br/>[3]Wan J, et al. Local recurrence of small cell lung cancer following radiofrequency ablation is induced by HIF-1α expression in the transition zone. Oncol Rep. 2016 Mar;35(3):1297-308.
Smiles	ClC1=CC=C(C=C1)NC2=NN=C(CC3=CC=NC=C3)C4=C2C=CC=C4
Alias	PTK787; ZK-222584; CGP-79787
Available
Product Description	Vatalanib (PTK787; ZK-222584; CGP-79787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	346.81
Clinical Information	Phase 3
Manufacturers Research Area	Cancer
Solubility	DMSO : 62.5 mg/mL (ultrasonic)
Target	VEGFR
Manufacturers Target	VEGFR
Isoform	VEGFR2/KDR/Flk-1
Manufacturers Pathway	Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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