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JNJ-39758979

JNJ-39758979

Item no.	HY-101189-25mg
Manufacturer	MedChem Express
CASRN	1046447-90-8
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Specific against	other
Purity	99.71
Citations	[1]Savall BM, et al. Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H4 receptor antagonists. J Med Chem. 2014 Mar 27;57(6):2429-39. [2]Murata Y, et al. Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4 R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis.
Smiles	NC1=NC(C(C)C)=CC(N2C[C@H](N)CC2)=N1
Available
Product Description	JNJ-39758979 is a selective, orally active, and high-affinity histamine H4 receptor antagonist with Kis of 12.5, 5.3, and 25 nM for human, mouse, and monkey histamine H4 receptor, respectively. JNJ-39758979 functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 shows good anti-inflammatory and antipruritic activity[1][2].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	221.30
Clinical Information	Phase 2
Manufacturers Research Area	Neurological Disease; Endocrinology
Solubility	DMSO : 33.33 mg/mL (ultrasonic)
Target	Histamine Receptor
Manufacturers Target	Histamine Receptor
Isoform	H4 Receptor
Manufacturers Pathway	GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Manufacturers Product type	Reference compound

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HY-101189-25mg-safety-datasheet.pdf