Anti-Hu CD79a Purified Monoclonal Antibody

Boster Bio Anti-Hu CD79a Purified Monoclonal Antibody (Catalog# M01047-4). Tested in Flow Cytometry, IP, WB, IHC-P application(s). This antibody reacts with Dog, Chicken, Rabbit, Guinea pig, Horse, Cow, Mouse, Rat, Pig, Primate, Human.

CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.

Monoclonal

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a. The mouse monoclonal antibody HM47 reacts with intracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.

Store at 2-8°C. Do not freeze.

25038 MW

Cell membrane; Single-pass type I membrane
protein. Following antigen binding, the BCR has been shown to
translocate from detergent-soluble regions of the cell membrane to
lipid rafts although signal transduction through the complex can
also occur outside lipid rafts.

B-cell antigen receptor complex-associated protein alpha chain