Item no. |
BOS-M00325-30ul |
Manufacturer |
Boster
|
Amount |
30ul |
Format |
Liquid |
Applications |
WB, IP |
Clone |
HED-8 |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
Alias |
Histone deacetylase 2;HD2;3.5.1.98;HDAC2; |
Available |
|
Manufacturers Product Category |
Primary Antibodies, Rabbit Monoclonal Antibodies |
Manufacturers Research Category |
Acetylation, Cardiovascular, Chromatin Modifying Enzymes, Class I, Epigenetics and Nuclear Signaling, Hypertrophy, Signaling Pathways, Stem Cells |
Short Description |
Boster Bio Anti-HDAC2/Histone Deacetylase 2 Rabbit Monoclonal Antibody catalog # M00325. Tested in WB, IP applications. This antibody reacts with Human, Mouse, Rat. |
Description |
Boster Bio Anti-HDAC2/Histone Deacetylase 2 Rabbit Monoclonal Antibody catalog # M00325. Tested in WB, IP applications. This antibody reacts with Human, Mouse, Rat. |
Gene Name |
HDAC2 |
Application Details |
WB 1:5000-1:10000 IP 1:50 |
Clonality |
Monoclonal |
Concentration |
Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
Immunogen |
A synthesized peptide derived from human HDAC2 |
Purification |
Affinity-chromatography |
Storage |
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Gene Full Name |
Histone deacetylase 2 |
Molecular Weight |
55364 MW |
Protein Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.. |
Subcellular Localization |
Nucleus. Cytoplasm. |
Tissue Specificity |
Widely expressed; lower levels in brain and lung. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.