Item no. |
BOS-M00303-30ul |
Manufacturer |
Boster
|
Amount |
30ul |
Format |
Liquid |
Applications |
WB, IP |
Clone |
BHO-22 |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
Alias |
Vasodilator-stimulated phosphoprotein;VASP;VASP; |
Available |
|
Manufacturers Product Category |
Primary Antibodies, Rabbit Monoclonal Antibodies |
Manufacturers Research Category |
Cytoskeleton/ECM, Extracellular Matrix, Signal Transduction, Structures |
Short Description |
Boster Bio Anti-VASP Rabbit Monoclonal Antibody catalog # M00303. Tested in WB, IP applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-VASP Rabbit Monoclonal Antibody catalog # M00303. Tested in WB, IP applications. This antibody reacts with Human. |
Gene Name |
VASP |
Application Details |
WB 1:500-1:2000 IP 1:50 |
Clonality |
Monoclonal |
Concentration |
Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. |
Immunogen |
A synthesized peptide derived from human VASP |
Purification |
Affinity-chromatography |
Storage |
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Gene Full Name |
Vasodilator-stimulated phosphoprotein |
Molecular Weight |
39830 MW |
Protein Function |
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin- bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation.. |
Subcellular Localization |
Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell junction, tight junction. Cell projection, lamellipodium membrane. Cell projection, filopodium membrane. Targeted to stress fibers and focal adhesions through interaction with a number of proteins including MRL family members. Localizes to the plasma membrane in protruding lamellipodia and filopodial tips. Stimulation by thrombin or PMA, also translocates VASP to focal adhesions. Localized along the sides of actin filaments throughout the peripheral cytoplasm under basal conditions. In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes). |
Tissue Specificity |
Highly expressed in platelets.. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.