Anti-PD-1 Pdcd1 Monoclonal Antibody [7A11B1]

Primary Antibodies, Monoclonal Antibodies

Boster Bio Anti-PD-1 Pdcd1 Monoclonal Antibody [7A11B1] (Catalog # M00178-3). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

Monoclonal

PD-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

A ~150 amino acid recombinant protein from near the amino terminus of mouse PD-1.

PD-1 monoclonal antibody can be stored at -20°C, stable for one year.

31842 MW

Membrane; Single-pass type I membrane
protein.

Programmed cell death 1