Item no. |
BOS-FC00137-FITC-1-200tests |
Manufacturer |
Boster
|
Amount |
200 tests |
Format |
Liquid |
Applications |
FC |
Clone |
M5E2 |
Specific against |
Human |
Host |
Mouse |
Isotype |
IgG2a Kappa |
Conjugate/Tag |
FITC |
Alias |
Monocyte differentiation antigen CD14 ;Myeloid cell-specific leucine-rich glycoprotein;CD14;Monocyte differentiation antigen CD14, urinary form;Monocyte differentiation antigen CD14, membrane-bound form;CD14; |
Available |
|
Manufacturers Product Category |
Primary Antibodies, Monoclonal Antibodies |
Manufacturers Research Category |
Cell Type Markers, Hematopoietic Progenitors, Immunology, Innate Immunity, Mesenchymal Stem Cells, Myeloid, Stem Cells, TLR Signaling |
Short Description |
Boster Bio Anti-Human CD14 Monoclonal Antibody FITC Conjugated, Flow Validated (Catalog# FC00137-FITC-1). Tested in Flow Cytometry application(s). This antibody reacts with Human. |
Description |
Boster Bio Anti-Human CD14 Monoclonal Antibody FITC Conjugated, Flow Validated (Catalog# FC00137-FITC-1). Tested in Flow Cytometry application(s). This antibody reacts with Human. |
Gene Name |
CD14 |
Clonality |
Monoclonal |
Concentration |
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
PBS pH 7.2, 0.2% (w/v) BSA, 0.09% (w/v) sodium azide |
Application Details |
User needs to optimize the dilution ratio for this antibody. |
Immunogen |
Full-length human CD14 protein |
Purification |
Affinity column chromatography |
Storage |
Store at 2-8°C. Avoid repeated freeze-thaw cycles. |
Gene Full Name |
Monocyte differentiation antigen CD14 |
Molecular Weight |
40076 MW |
Protein Function |
Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL (-)) and mediates the cytokine release induced by LDL (-) (PubMed:23880187).. |
Subcellular Localization |
Cell membrane; Lipid- anchor, GPI-anchor. Secreted. Membrane raft. Golgi apparatus. Secreted forms may arise by cleavage of the GPI anchor. |
Tissue Specificity |
Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages. |
Format Information |
Liquid, in PBS, pH7.2, <0.09% NaN3 and 0.2% (w/v) BSA |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.