Item no. |
BOS-A15565 |
Manufacturer |
Boster
|
Amount |
0.1mg |
Format |
Liquid |
Applications |
WB, IF, ELISA, IHC-P |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
Alias |
TMEM94, TMEM94, Uncharacterized protein KIAA0195, Transmembrane protein 94 |
Available |
|
Manufacturers Product Category |
Primary Antibodies |
Manufacturers Research Category |
Neuroscience |
Short Description |
Boster Bio Anti-FRMPD4 TMEM94 Antibody (Catalog # A15565). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-FRMPD4 TMEM94 Antibody (Catalog # A15565). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human. |
Background |
The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD4, also known as Preso, also contains another protein interaction domain termed WW (domain with two conserved Trp residues) at its amino terminus. It was identified through a yeast two-hybrid screen using the PDZ domain of PSD-95 as bait and is highly expressed in multiple regions of the brain and is enriched in the postsynaptic density (PSD) fractions. Overexpression of FRMPD4 in cultured hippocampal neurons significantly increased the linear density of dendritic spines without changing their length and width; conversely, knockdown experiments using RNAi caused a decrease in spine density, indicating FRMPD4 positively regulates dendritic spine density but not morphology. The decreased level of FRMPD4 also resulted in reduced levels of excitatory synaptic transmission, suggesting that FRMPD4 is required for maintenance of excitatory synaptic transmission. |
Gene Name |
KIAA0195 |
Clonality |
Polyclonal |
Concentration |
1 mg/mL |
Contents |
FRMPD4 Antibody is supplied in PBS containing 0.02% sodium azide. |
Predicted Reactivity |
Mouse |
Application Details |
FRMPD4 antibody can be used for detection of FRMPD4 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher. |
Immunogen |
FRMPD4 antibody was raised against an 18 amino acid synthetic peptide from near the center of human FRMPD4. The immunogen is located within amino acids 620 - 670 of FRMPD4. |
Purification |
FRMPD4 Antibody is affinity chromatography purified via peptide column. |
Storage |
FRMPD4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Gene Full Name |
KIAA0195 |
Molecular Weight |
151151 MW |
Subcellular Localization |
Membrane ; Multi-pass membrane protein. |
Tissue Specificity |
Expressed ubiquitously. |
Protein Name |
KIAA0195 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.