Anti-MICOS complex subunit MIC25 CHCHD6 Antibody

Primary Antibodies

Boster Bio Anti-MICOS complex subunit MIC25 CHCHD6 Antibody (Catalog # A09965). Tested in ELISA, WB applications. This antibody reacts with Human.

CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.

Polyclonal

CHCHD6 Antibody is supplied in PBS containing 0.02% sodium azide.

Rabbit polyclonal CHCHD6 antibody was raised against a 17 amino acid peptide near the amino terminus of human CHCHD6. The immunogen is located within amino acids 20 - 70 of CHCHD6.

CHCHD6 Antibody is affinity chromatography purified via peptide column.

Coiled-coil-helix-coiled-coil-helix domain containing 6

Component of the MICOS complex, a large protein complex
of the mitochondrial inner membrane that plays crucial roles in
the maintenance of crista junctions, inner membrane architecture,
and formation of contact sites to the outer membrane.

Coiled-coil-helix-coiled-coil-helix domain containing 6