Item no. |
BOS-A09733 |
Manufacturer |
Boster
|
Amount |
0.1mg |
Format |
Liquid |
Applications |
WB, IF, ELISA, IHC-P |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
Alias |
BOCT, BOIT, 24p3R, NGALR, hBOIT, NGALR2, NGALR3, BOCT, Solute carrier family 22 member 17, 24p3 receptor |
Available |
|
Manufacturers Product Category |
Primary Antibodies |
Manufacturers Research Category |
Homeostasis |
Short Description |
Boster Bio Anti-Slc22A17 Antibody (Catalog # A09733). Tested in ELISA, WB, IF, IHC-P applications. This antibody reacts with Human, Mouse, Rat. |
Description |
Boster Bio Anti-Slc22A17 Antibody (Catalog # A09733). Tested in ELISA, WB, IF, IHC-P applications. This antibody reacts with Human, Mouse, Rat. |
Background |
The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. Each contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways such as uniporters that mediate facilitated diffusion in either direction (OCTs), as anion exchangers (OAT1, OAT3 and URAT1), and as Na(+)/l-carnitine cotransporter (OCTN2). Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart. Mutations in the Slc22 family may cause specific diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may change drug absorption or excretion. Recent studies show the expression of Slc22A17 as receptor for Lipocalin 2 is relatively high in hematopoietic stem cells. |
Gene Name |
SLC22A17 |
Clonality |
Polyclonal |
Concentration |
1 mg/mL |
Contents |
Slc22A17 Antibody is supplied in PBS containing 0.02% sodium azide. |
Predicted Reactivity |
Bovine |
Application Details |
Slc22A17 antibody can be used for detection of Slc22A17 by Western blot at 0.5 μg/mL. Antibody can also be used for immunoflourescence starting at 20 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse and rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher. |
Immunogen |
Slc22A17 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human Slc22A17. The immunogen is located within the last 50 amino acids of Slc22A17. |
Purification |
Slc22A17 Antibody is affinity chromatography purified via peptide column. |
Storage |
Slc22A17 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Gene Full Name |
Solute carrier family 22, member 17 |
Molecular Weight |
57686 MW |
Protein Function |
Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).. |
Subcellular Localization |
Cell membrane |
Tissue Specificity |
Expressed in brain. |
Protein Name |
Solute carrier family 22, member 17 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.