Anti-Slc22A17 Antibody

Primary Antibodies

Boster Bio Anti-Slc22A17 Antibody (Catalog # A09733). Tested in ELISA, WB, IF, IHC-P applications. This antibody reacts with Human, Mouse, Rat.

The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. Each contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways such as uniporters that mediate facilitated diffusion in either direction (OCTs), as anion exchangers (OAT1, OAT3 and URAT1), and as Na(+)/l-carnitine cotransporter (OCTN2). Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart. Mutations in the Slc22 family may cause specific diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may change drug absorption or excretion. Recent studies show the expression of Slc22A17 as receptor for Lipocalin 2 is relatively high in hematopoietic stem cells.

Polyclonal

Slc22A17 Antibody is supplied in PBS containing 0.02% sodium azide.

Slc22A17 antibody can be used for detection of Slc22A17 by Western blot at 0.5 μg/mL. Antibody can also be used for immunoflourescence starting at 20 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse and rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Slc22A17 Antibody is affinity chromatography purified via peptide column.

Solute carrier family 22, member 17

Cell surface receptor for LCN2 (24p3) that plays a key
role in iron homeostasis and transport. Able to bind iron-bound
LCN2 (holo-24p3), followed by internalization of holo-24p3 and
release of iron, thereby increasing intracellular iron
concentration and leading to inhibition of apoptosis. Also binds
iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3
and its association with an intracellular siderophore, leading to
iron chelation and iron transfer to the extracellular medium,
thereby reducing intracellular iron concentration and resulting in
apoptosis (By similarity)..

Expressed in brain.