Anti-LZTS2 Antibody

Primary Antibodies

Boster Bio Anti-LZTS2 Antibody (Catalog # A07806-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.

The leucine zipper putative tumor suppressor 2 (LZTS2, also known as LAPSER1), a member of the LZTS family, is a negative regulator of the Wnt signaling pathway. It represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. LZTS2 is involved in cytokinesis and regulates katanin-mediated microtubule severing and release from the centrosome. LZTS2 may negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. LZTS2 is highly expressed in testis and prostate, but it is deleted in multiple cancers, including prostate tumors, suggesting that LZTS2 acts as a potential tumor suppressor.

Polyclonal

LZTS2 Antibody is supplied in PBS containing 0.02% sodium azide.

LZTS2 antibody can be used for detection of EPAC1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

LZTS2 antibody is predicted to not cross-react with other LZTS family members

LZTS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

72759 MW

Cytoplasm. Cytoplasm, cytoskeleton,
microtubule organizing center, centrosome. Localized to the
centrosome throughout the cell cycle. Localized to the midbody in
cells undergoing cytokinesis.

Leucine zipper, putative tumor suppressor 2