Item no. |
BOS-A07806-1 |
Manufacturer |
Boster
|
Amount |
0.1mg |
Format |
Liquid |
Applications |
WB, IF, ELISA, IHC-P |
Specific against |
Human, Mouse |
Host |
Rabbit |
Isotype |
IgG |
Alias |
LAPSER1, KIAA1813, LAPSER1, Leucine zipper putative tumor suppressor 2, Protein LAPSER1, hLZTS2 |
Available |
|
Manufacturers Product Category |
Primary Antibodies |
Manufacturers Research Category |
Cancer, Cell Cycle |
Short Description |
Boster Bio Anti-LZTS2 Antibody (Catalog # A07806-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse. |
Description |
Boster Bio Anti-LZTS2 Antibody (Catalog # A07806-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse. |
Background |
The leucine zipper putative tumor suppressor 2 (LZTS2, also known as LAPSER1), a member of the LZTS family, is a negative regulator of the Wnt signaling pathway. It represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. LZTS2 is involved in cytokinesis and regulates katanin-mediated microtubule severing and release from the centrosome. LZTS2 may negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. LZTS2 is highly expressed in testis and prostate, but it is deleted in multiple cancers, including prostate tumors, suggesting that LZTS2 acts as a potential tumor suppressor. |
Gene Name |
LZTS2 |
Clonality |
Polyclonal |
Concentration |
1 mg/mL |
Contents |
LZTS2 Antibody is supplied in PBS containing 0.02% sodium azide. |
Predicted Reactivity |
Rat, Bovine |
Application Details |
LZTS2 antibody can be used for detection of EPAC1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher. |
Immunogen |
LZTS2 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human LZTS2. The immunogen is located within amino acids 80 - 130 of LZTS2. |
Cross-reactivity |
LZTS2 antibody is predicted to not cross-react with other LZTS family members |
Purification |
LZTS2 Antibody is affinity chromatography purified via peptide column. |
Storage |
LZTS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Gene Full Name |
Leucine zipper, putative tumor suppressor 2 |
Molecular Weight |
72759 MW |
Protein Function |
Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. |
Subcellular Localization |
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis. |
Tissue Specificity |
Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon. |
Protein Name |
Leucine zipper, putative tumor suppressor 2 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.