Item no. |
BOS-A06336 |
Manufacturer |
Boster
|
Amount |
0.1mg |
Format |
Liquid |
Applications |
WB, ICC, ELISA |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
Alias |
Inositol polyphosphate-4-phosphatase type II 105kDa |
Available |
|
Manufacturers Product Category |
Primary Antibodies |
Manufacturers Research Category |
Cancer, Cell Cycle |
Short Description |
Boster Bio Anti-INPP4B Antibody (Catalog # A06336). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse, Rat. |
Description |
Boster Bio Anti-INPP4B Antibody (Catalog # A06336). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse, Rat. |
Background |
Inositol polyphosphate 4-phosphatase type II (INPP4B) is one of the enzymes involved in phosphatidylinositol signaling pathways. It removes the phosphate group at position 4 of the inositol ring from inositol 3, 4-bisphosphate (1). INPP4B can function as a tumor suppressor by inhibiting PI3K signaling. In human epithelial cells, knockdown of INPP4B expression resulted in enhanced Akt activation, anchorage-independent growth, and enhanced overall motility (2). It is thought INPP4B may also have oncogenic functions as INPP4B-dependent PI3K signaling is mediated by SGK3 in breast cancer cells and expression of INPP4B leads to enhanced SGK3 activation and suppression of AKT phosphorylation (3). |
Gene Name |
INPP4B |
Clonality |
Polyclonal |
Concentration |
1 mg/mL |
Contents |
INPP4B antibody is supplied in PBS containing 0.02% sodium azide. |
Application Details |
INPP4B antibody can be used for detection of INPP4B by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. Antibody validated: Western Blot in mouse samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher. |
Immunogen |
INPP4B antibody was raised against a 17 amino acid peptide near the amino terminus of human INPP4B. The immunogen is located within the last 50 amino acids of INPP4B. |
Cross-reactivity |
INPP4B antibody is human, mouse and rat reactive. At least two isoforms of INPP4B are known to exist; this antibody only detects the longer isoform. INPP4B antibody is predicted to not cross-react with INPP4A. |
Purification |
INPP4B antibody is affinity chromatography purified via peptide column. |
Storage |
INPP4B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. |
Gene Full Name |
Inositol polyphosphate-4-phosphatase, type II, 105kDa |
Protein Name |
Inositol polyphosphate-4-phosphatase, type II, 105kDa |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.