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Anti-Vinexin/SORBS3 Antibody Picoband™

Anti-Vinexin/SORBS3 Antibody Picoband™

Item no.	BOS-A05794-10ug
Manufacturer	Boster
Amount	10ug
Format	Lyophilized
Applications	WB, FC, IF, IHC, ICC
Specific against	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
Alias	Vinexin; SH3-containing adapter molecule 1; SCAM-1; Sorbin and SH3 domain-containing protein 3; SORBS3; SCAM1
Available
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Short Description	Boster Bio Anti-Vinexin/SORBS3 Antibody Picoband™ catalog # A05794. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-Vinexin/SORBS3 Antibody Picoband™ catalog # A05794. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
Background	Vinexin is a protein that in humans is encoded by the SORBS3 gene. It is mapped to 8p21.3. This gene encodes an SH3 domain-containing adaptor protein. The presence of SH3 domains play a role in this protein's ability to bind other cytoplasmic molecules and contribute to cystoskeletal organization, cell adhesion and migration, signaling, and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name	SORBS3
Application Details	Western blot, 0.25-0.5μg/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 2μg/ml, Human Flow Cytometry, 1-3μg/1x10⁶ cells, Human
Application Notes	Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminus of human Vinexin/SORBS3, which shares 87.5% and 84.4% amino acid (aa) sequence identity with mouse and rat Vinexin/SORBS3, respectively.
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins.
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	sorbin and SH3 domain containing 3
Molecular Weight	87 kDa
Protein Function	Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
Subcellular Localization	Cytoskeleton. Cell junction. Nucleus. Cytoskeleton. Cell junction.
Tissue Specificity	Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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