Item no. |
BOS-A05286 |
Manufacturer |
Boster
|
Amount |
0.1mg |
Format |
Liquid |
Applications |
WB, IF, ELISA, IHC-P |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
Alias |
NAP, P14L, PP8304, C20orf33, dJ633O20.1, Beta-catenin-like protein 1, Nuclear-associated protein, NAP |
Available |
|
Manufacturers Product Category |
Primary Antibodies |
Manufacturers Research Category |
Apoptosis |
Short Description |
Boster Bio Anti-CTTNBL1 CTNNBL1 Antibody (Catalog # A05286). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat. |
Description |
Boster Bio Anti-CTTNBL1 CTNNBL1 Antibody (Catalog # A05286). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat. |
Background |
The Beta-catenin-like protein 1 (CTNNBL1) contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs, as well as Armadillo/beta-catenin-like repeats. Transient expression of CTNNBL1 resulted in translocation to the nucleus and apoptosis, suggesting it may be involved in the apoptotic pathway. CTNNBL1 interacts with the Prp19 complex of the spliceosome and the Ig class switching enzyme activation-induced deaminase (AID) and had been suggested to play a role in antibody-diversification and class switching, but recent studies have shown CTNNBL1 to be dispensable for Ig class switch recombination. Other studies have identified CTTNBL1 as a novel gene for obesity. |
Gene Name |
CTNNBL1 |
Clonality |
Polyclonal |
Concentration |
1 mg/mL |
Contents |
CTTNBL1 Antibody is supplied in PBS containing 0.02% sodium azide. |
Predicted Reactivity |
Bovine |
Application Details |
CTTNBL1 antibody can be used for detection of CTTNBL1 by Western blot at 1 and 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher. |
Immunogen |
CTTNBL1 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human CTTNBL1. The immunogen is located within the last 50 amino acids of CTTNBL1. |
Cross-reactivity |
CTNNBL1 antibody is predicted to not cross-react with other catenin family members. At least four isoforms of CTNNBL1 are known to exist; this antibody will detect all but isoform b. |
Purification |
CTTNBL1 Antibody is affinity chromatography purified via peptide column. |
Storage |
CTTNBL1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Gene Full Name |
Catenin, beta like 1 |
Molecular Weight |
65173 MW |
Protein Function |
Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis. |
Subcellular Localization |
Isoform 1: Nucleus. |
Tissue Specificity |
Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid. |
Protein Name |
Catenin, beta like 1 |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.