Anti-Prickle-like protein 1 PRICKLE1 Antibody

Primary Antibodies

Boster Bio Anti-Prickle-like protein 1 PRICKLE1 Antibody (Catalog # A05038). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

PRICKLE1, also known as RILP or EPM1B, is a Disheveled-associated protein that serves as a nuclear translocation receptor for REST/NRSF and REST4 (1, 2). It contains three N-terminal LIM domains and three C-terminal nuclear localization signals. It localizes to the cytoplasm, as well as to the nuclear membrane and expressed at higher levels in placenta. PRICKLE1 is a negative regulator of the Wnt / beta-catenin signaling pathway and is a putative tumor suppressor in human HCCs. Defects in the gene encoding PRICKLE1 are associated with autosomal recessive progressive myoclonic epilepsy.

Polyclonal

PRICKLE1 Antibody is supplied in PBS containing 0.02% sodium azide.

PRICKLE1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human PRICKLE1. The immunogen is located within the last 50 amino acids of PRICKLE1.

PRICKLE1 Antibody is affinity chromatography purified via peptide column.

Prickle homolog 1

Involved in the planar cell polarity pathway that
controls convergent extension during gastrulation and neural tube
closure. Convergent extension is a complex morphogenetic process
during which cells elongate, move mediolaterally, and intercalate
between neighboring cells, leading to convergence toward the
mediolateral axis and extension along the anteroposterior axis.
Necessary for nuclear localization of REST. May serve as nuclear
receptor.

Expressed at highest levels in placenta and at
lower levels in lung, liver, kidney and pancreas. Expressed in
thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons
rather than glia).