Item no. |
BOS-A04986 |
Manufacturer |
Boster
|
Amount |
0.1mg |
Format |
Liquid |
Applications |
WB, ELISA |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
Alias |
Fasciculation and elongation protein zeta-1, Zygin I |
Available |
|
Manufacturers Product Category |
Primary Antibodies |
Manufacturers Research Category |
Neuroscience |
Short Description |
Boster Bio Anti-FEZ1 Antibody (Catalog # A04986). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. |
Description |
Boster Bio Anti-FEZ1 Antibody (Catalog # A04986). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. |
Background |
Similar to its C. elegans homolog UNC-76, mammalian FEZ1, an abundant membrane protein and protein kinase C (PKC)-Z substrate, is involved in axonal guidance. Following phosphorylation by PKC-Z, FEZ1 translocates from the plasma membrane to the cytoplasm. FEZ1 is then able to interact with a number of proteins involved in axonal outgrowth and cellular transport such as DISC1, a candidate gene for schizophrenia, as well as kinesin-1, a microtubule-based motor protein. FEZ1 also interacts with proteins involved in transcriptional regulation and chromatin remodeling, suggesting that FEZ1 may have nuclear regulatory functions in addition to those for neuronal development. At least two distinct isoforms of FEZ1 are known to exist. |
Gene Name |
FEZ1 |
Clonality |
Polyclonal |
Concentration |
1 mg/mL |
Contents |
FEZ1 Antibody is supplied in PBS containing 0.02% sodium azide. |
Application Details |
FEZ1 antibody can be used for the detection of FEZ1 by Western blot at 0.5 - 1 μg/mL. Despite its predicted molecular weight, FEZ1 will often run at higher molecular weight in SDS-PAGE. Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher. |
Immunogen |
FEZ1 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human FEZ1. The immunogen is located within amino acids 270 - 320 of FEZ1. |
Purification |
FEZ1 Antibody is affinity chromatography purified via peptide column. |
Storage |
FEZ1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Gene Full Name |
Fasciculation and elongation protein zeta 1 (zygin I) |
Molecular Weight |
45119 MW |
Protein Function |
May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. |
Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
Tissue Specificity |
Mainly expressed in brain. |
Protein Name |
Fasciculation and elongation protein zeta 1 (zygin I) |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.