« Back
Home /
Anti-CREB3 Antibody

Anti-CREB3 Antibody

Item no.	BOS-A03564-1
Manufacturer	Boster
Amount	100ul
Format	Liquid
Applications	WB, ELISA
Specific against	Human, Mouse, Rat
Host	Rabbit
Alias	Cyclic AMP-responsive element-binding protein 3;CREB-3;cAMP-responsive element-binding protein 3;Leucine zipper protein;Luman;Transcription factor LZIP-alpha;Processed cyclic AMP-responsive element-binding protein 3;N-terminal Luman;Transcriptionally active form;CREB3;LZIP;
Available
Manufacturers Product Category	Primary Antibodies
Short Description	Boster Bio Anti-CREB3 Antibody catalog # A03564-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-CREB3 Antibody catalog # A03564-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Gene Name	CREB3
Clonality	Polyclonal
Concentration	1 mg/mL
Contents	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Application Details	WB 1:500-2000 ELISA 1:10000-20000
Immunogen	Synthesized peptide derived from CREB3 at AA range: 151-200.
Purification	Immunogen affinity purified
Storage	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Gene Full Name	Cyclic AMP-responsive element-binding protein 3
Molecular Weight	43917 MW
Protein Function	Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and migration, tumor suppression and inflammatory gene expression. Plays also a role in the human immunodeficiency virus type 1 (HIV-1) virus protein expression and in the herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Isoform 2 plays a role in the unfolded protein response (UPR). Isoform 2 acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Isoform 2 may play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HSV) core protein. Isoform 2 represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestring host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection. Isoform 3 functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Isoform 3 decreases the acetylation level of histone H4. Isoform 3 does not promote the chemotactic activity of leukocyte cells.
Subcellular Localization	Isoform 2: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Membrane. Colocalizes with HCFC1 in neuronal cell bodies of the trigeminal ganglia (By similarity). Colocalizes with TM7SF4 in the ER membrane of immature dendritic cell (DC). Colocalizes with CANX, CCR1, HCFC1 in the ER membrane. Sequestred into the cytoplasm by the HCV core protein..
Tissue Specificity	Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level). Ubiquitous..

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 100ul

available

Delivery expected until 8/30/2024

Express Delivery: Save 3 days

Compare

Add to wishlist

Recommend by mail