Anti-SESTRIN2 SESN2 Antibody

Autophagy, Homeostasis

Boster Bio Anti-SESTRIN2 SESN2 Antibody (Catalog # A02558). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

SESN2

1 mg/mL

Bovine

SESTRIN2 antibody was raised against a 19 amino acid peptide near the center of human SESTRIN2. The immunogen is located within amino acids 220 - 270 of SESTRIN2.

SESTRIN2 antibody is affinity chromatography purified via peptide column.

Sestrin 2

Functions as an intracellular leucine sensor that
negatively regulates the TORC1 signaling pathway through the GATOR
complex. In absence of leucine, binds the GATOR subcomplex GATOR2
and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562,
PubMed:25457612, PubMed:26449471, PubMed:26612684,
PubMed:26586190). Binding of leucine to SESN2 disrupts its
interaction with GATOR2 thereby activating the TORC1 signaling
pathway (PubMed:26449471, PubMed:26586190). This stress-inducible
metabolic regulator also plays a role in protection against
oxidative and genotoxic stresses. May negatively regulate protein
translation in response to endoplasmic reticulum stress, via TORC1
(PubMed:24947615). May positively regulate the transcription by
NFE2L2 of genes involved in the response to oxidative stress by
facilitating the SQSTM1-mediated autophagic degradation of KEAP1
(PubMed:23274085). May also mediate TP53 inhibition of TORC1
signaling upon genotoxic stress (PubMed:18692468). Has an
alkylhydroperoxide reductase activity born by the N-terminal
domain of the protein (PubMed:26612684). Was originally reported
to contribute to oxidative stress resistance by reducing PRDX1
(PubMed:15105503). However, this could not be confirmed
(PubMed:19113821).

Widely expressed.