Anti-Bcl-2-modifying factor Bmf Antibody

Primary Antibodies

Boster Bio Anti-Bcl-2-modifying factor Bmf Antibody (Catalog # A02432). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.

Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifing factor). The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program. Bmf is constitutively expressed in many tissues.

Polyclonal

Bmf Antibody is supplied in PBS containing 0.02% sodium azide.

Bmf antibody was raised with a synthetic peptide corresponding to 14 amino acids near the carboxy terminus of human Bmf. The immunogen is located within the last 50 amino acids of Bmf.

Bmf antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

20508 MW

Isoform 2: Mitochondrion membrane
; Single-pass membrane protein. Nucleus
.

Bcl2 modifying factor