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Anti-Bcl-2/BCL2 Antibody Picoband™

Anti-Bcl-2/BCL2 Antibody Picoband™

Item no.	BOS-A00040-2-10ug
Manufacturer	Boster
Amount	10ug
Format	Lyophilized
Applications	WB, FC, IF, ICC, ELISA
Specific against	Human
Host	Rabbit
Isotype	IgG
Alias	Apoptosis regulator Bcl-2; BCL2
Available
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category	Apoptosis, Apoptotic Markers, Cancer, Cancer Metabolism, Cell Biology, Cell Death, Hypoxia, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Oncoproteins, Oncoproteins/Suppressors, Pathways and Processes, Response To Hypoxia, Signal Transduction, Tumor Biomarkers
Short Description	Boster Bio Anti-Bcl-2/BCL2 Antibody Picoband™ catalog # A00040-2. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-Bcl-2/BCL2 Antibody Picoband™ catalog # A00040-2. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human.
Background	Immunoreactive BCL2 protein in the neoplastic cells of almost all follicular lymphomas whereas no BCL2 protein was detected in follicles affected by nonneoplastic processes or in normal lymphoid tissue. Every tumor with molecular-genetic evidence of t (14; 18) translocation expressed detectable levels of BCL2 protein, regardless of whether the breakpoint was located in or at a distance from the BCL2 gene. Overexpression of BCL2 blocks the apoptotic death of a pro-B-lymphocyte cell line.
Gene Name	BCL2
Application Details	Western blot, 0.1-0.5μg/ml, Human Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human Flow Cytometry, 1-3 μg/1x10⁶ cells, Human
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
Immunogen	E. coli-derived human Bcl-2 recombinant protein (Position: Q118-E165).
Cross-reactivity	No cross-reactivity with other proteins.
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	BCL2, apoptosis regulator
Molecular Weight	26 kDa
Protein Function	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Subcellular Localization	Mitochondrion outer membrane.
Tissue Specificity	Expressed in a variety of tissues.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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