OM99-2

Item no.	HY-P2713-100mg
Manufacturer	MedChem Express
CASRN	314266-76-7
Amount	100 mg
Category	Peptides & Proteins Peptides
Type	Peptides
Specific against	other
Citations	[1]Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523.<br>[2]Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4.<br>[3]Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119.<br>[4]Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422.
Smiles	OC([C@H](CC1=CC=CC=C1)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](C)C[C@H](O)[C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](C(C)C)NC([C@@H](N)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O
ECLASS 5.1	34160400
ECLASS 6.1	34160400
ECLASS 8.0	32160409
ECLASS 9.0	32160409
ECLASS 10.0.1	32160409
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Product Description	OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 is significantly advanced the development of BACE1 inhibitor[2]. OM99-2 has the potential for the research of the Alzheimer's disease[3].
Shipping	Room temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	892.99
Clinical_Information	No Development Reported
Manufacturers Research_Area	Neurological Disease
Solubility	10 mM in DMSO
Manufacturers Target	Beta-secretase
Isoform	BACE1
Pathway	Neuronal Signaling
Manufacturers Product type	Peptides

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