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Verucopeptin

Verucopeptin

Item no.	HY-P2657-50ug
Manufacturer	MedChem Express
CASRN	138067-14-8
Amount	50 ug
Quantity options	100 ug 25 ug 50 ug
Category	Peptides & Proteins Peptides
Type	Peptides
Specific against	other
Purity	99.0
Formula	C43H73N7O13
Citations	[1]Aya Yoshimura, et al.Structure Elucidation of Verucopeptin, a HIF-1 Inhibitory Polyketide-Hexapeptide Hybrid Metabolite from an Actinomycete. Org Lett. 2015 Nov 6;17(21):5364-7. [2]Nobuaki Takahashi, et al. Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1). Chem Commun (Camb). 2019 Oct 1;55(79):11956-11959. [3]Yuezhou Wang, et al. Pharmacological Targeting of Vacuolar H +-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Jun 30;S2451-9456(20)30234-8.
Smiles	O=C([C@@](O)(C(O[C@@H]1/C(C)=C/[C@@H](C)C[C@@H](C)C[C@H](C)CC)(CC[C@@H]1OC)O)C)N[C@H](C(N(NCCC2)[C@@]2([H])C(N(CC(N(C3)C)=O)O)=O)=O)[C@@H](OC(CN(C(CNC3=O)=O)C)=O)C(C)C
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	138067-14-8
Shipping Condition	Cool pack
Available
Manufacturer - Type	Peptides
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Endogenous Metabolite; HIF/HIF Prolyl-Hydroxylase; Proton Pump
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Molecular Weight	896.08
Product Description	Verucopeptin is a potent HIF-1 (IC50=0.22 μM) inhibitor and decreases the expression of HIF-1 target genes and HIF-1α protein levels. Verucopeptin strongly inhibits v-ATPase activity by directly targeting the v-ATPase ATP6V1G subunit but not ATP1V1B2 or ATP6V1D. Verucopeptin exhibits antitumor activity against multidrug resistance (MDR) cancers and can be used for cancer research.
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-P2657-50ug-safety-datasheet.pdf