Bio Background |
LAR is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. |
Bio References |
Blanchetot, C., et al., J. Biol. Chem. 277(49):47263-47269 (2002).Tsujikawa, K., et al., Mol. Cancer Res. 1(2):155-163 (2002).Zabolotny, J.M., et al., Proc. Natl. Acad. Sci. U.S.A. 98(9):5187-5192 (2001).Muller, T., et al., J. Biol. Chem. 274(15):10173-10183 (1999).Ahmad, F., et al., J. Biol. Chem. 272(1):448-457 (1997). |