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Caspase-9, CASP9, MCH6, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, ICE-like apoptotic protease 6, Caspase-9 subunit p35, Caspase-9 subunit p10, APAF-3, ICE-LAP6, CASP-9 |
Bio Background |
Caspase 9 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. |
Bio References |
Martin, M.C., et al., J. Biol. Chem. 280(15):15449-15455 (2005).Raina, D., et al., J. Biol. Chem. 280(12):11147-11151 (2005).Cornelis, S., et al., Oncogene 24(9):1552-1562 (2005).Mohammad, R.M., et al., Mol. Cancer Ther. 4(1):13-21 (2005).Tacconi, S., et al., Exp. Neurol. 190(1):254-262 (2004). |