Bio Background |
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. |
Bio References |
Moshinsky, D.J., et al., Biochem. Biophys. Res. Commun. 310(3):1026-1031 (2003).Chow, J.P., et al., J. Biol. Chem. 278(42):40815-40828 (2003).O'Nions, J., et al., Oncogene 22(46):7181-7191 (2003).Yun, J., et al., J. Biol. Chem. 278(38):36966-36972 (2003).Izumiya, Y., et al., J. Virol. 77(17):9652-9661 (2003). |