Item no. |
ABC-BP7294c |
Manufacturer |
Abcepta
|
Amount |
500 ug |
Category |
|
Type |
Peptides |
Format |
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Similar products |
DDR1, CD167a, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE, Epithelial discoidin domain-containing receptor 1, CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, Mammary carcinoma kinase 10, Protein-tyrosine kinase 3A, Epithelial discoidin domain receptor 1, TRK E, Tyrosine kinase DDR, MCK-10, Tyrosine-protein kinase CAK, Protein-tyrosine kinase RTK-6 |
Available |
|
Primary Accession |
Q08345 |
Bio Background |
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. DDR1 is an RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. It belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis show that expression of DDR1 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. |
Bio References |
Johnson J.D., Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681(1993)Sakuma S., FEBS Lett. 398:165-169(1996) |
Gene ID |
780 |
Gene Name |
DDR1 |
Subtitle |
Synthetic peptide |
Target/Specificity |
The synthetic peptide sequence used to generate the antibody AP7294c was selected from the Center region of human DDR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.